View on GitHub

The Todd Group

Home Research
Current Members Past Members Group Pictures
Publications News Internal

ORCID ID 0000-0001-7096-4751
Google Scholar

2024

  1. Reaction Hijacking Inhibition of Plasmodium falciparum Asparagine tRNA Synthetase, S. C. Xie, Y. Wang, C. J. Morton, R. D. Metcalfe, C. Dogovski, C. F. A. Pasaje, E. Dunn, M. R. Luth, K. Kumpornsin, E. S Istvan, J. S. Park, K. J. Fairhurst, N. Ketprasit, T. Yeo, O. Yildirim, M. N. Bhebhe, D. M. Klug, P. J. Rutledge, L. C. Godoy, S. Dey, M. L. De Souza, J. L. Siqueira-Neto, Y. Du, T. Puhalovich, M. Amini, G. Shami, D. Loesbanluechai, S. Nie, N. Williamson, G. P. Jana, B. C. Maity, P. Thomson, T. Foley, D. S. Tan, J. C. Niles, B. W. Han, D. E Goldberg, J. Burrows, D. A. Fidock, M. C. S. Lee, E. A. Winzeler, M. D. W. Griffin, M. H. Todd and L. Tilley, Nature Comms. 2024 in press. DOI: 10.1038/s41467-024-45224-z

2023

  1. Open Source Antibiotics - Simple Diarylimidazoles are Potent Against Methicillin Resistant Staphylococcus Aureus, D. M. Klug, E. G. Tse, D. G. Silva, Y. Cao, S. A. Charman, J. Chauhan, E. Crighton, M. Dichiara, C. Drake, D. Drewry, F. da Silva Emery, L. Ferrins, L. Graves, E. Hopkins, T. A. C. Kresina, Á. Lorente-Macías, B. Perry, R. Phipps, B. Quiroga, A. Quotadamo, G. Sabatino, A. Sama, A. Schätzlein, Q. J. Simpson, J. Steele, J. Shanu-Wilson, P. Sjö, P. Stapleton, C. Swain, A. Vaideanu, H. Xie, W. Zuercher, M. H. Todd, ACS Infect. Dis. 2023, in press. DOI: 10.1021/acsinfecdis.3c00286.

  2. Structure-property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis, M. Dichiara, Q. J. Simpson, A. Quotadamo, H. B. Jalani, A. X. Huang, C. C. Millard, D. M. Klug, E. G. Tse, M. H. Todd, D. Gedder, F. da Silva Emery, J. E. Carlson, S.-L. Zheng, M. Vleminckx, A. Matheeussen, G. Caljon, M. P. Pollastri, P. Sjö, B. Perry, L. Ferrins, ACS Infect. Dis. 2023, in press (id-2023-000406). DOI: 10.1021/acsinfecdis.3c00040.

  3. Perphenazine-macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid, S. R. Ball, J. S. P. Adamson, M. A. Sullivan, M. R. Zimmermann, V. Lo, M. Sanz-Hernandez, X. Jiang, A. H. Kwan, A. D. J. McKenzie, E. L. Werry, T. P. J. Knowles, M. Kassiou, G. Meisl, M. H. Todd, P. J. Rutledge, M. Sunde, ACS Chem. Neurosci. 2023, 14, 87-98. DOI: 10.1021/acschemneuro.2c00498

  4. Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella mycetomatis, J. Ma, M. H. Todd, W. W. J. van de Sande and B. Biersack, Chem. Biodiversity 2023, 20, e202300151. DOI: 10.1002/cbdv.202300151

  5. Target 2035–an Update on Private Sector Contributions, S. Ackloo, A. A. Antolin, J. M. Bartolome, H. Beck, A. N Bullock, U. A. K. Betz, J. Böttcher, P. J. Brown, M. Chaturvedi, A. Crisp, D. Daniels, J. Dreher, K. Edfeldt, A. M. Edwards, U. Egner, J. Elkins, C. Fischer, T. Glendorf, S. Goldberg, I. V. Hartung, A. Hillisch, E. Homan, S. Knapp, M. Koester, A. Kraemer, J. Llaveria, U. Lessel, S. Lindemann, L. Linderoth, H. Matsui, M. Michel, F. Montel, A. Mueller-Fahrnow, S, Mueller, D. R. Owen, K. S. Saikatendu, V. Santhakumar, W. Sanderson, C. Scholten, M. Schapira, S. Sharma, B. Shireman, M. Sundström, M. H. Todd, C. Tredup, J. Veneble, T. M. Willson, and C. H Arrowsmith, RSC Med. Chem. 2023, advance article. DOI: 10.1039/D2MD00441K

  6. Metallaphotoredox-Catalyzed Decarboxylative sp3–sp3 Coupling with Iso(thio)chroman and Tetrahydroisoquinoline Cores, P. A. King, P. J. Rutledge and M. H. Todd, submitted. Preprint.

2022

  1. CACHE (Critical Assessment of Computational Hit-finding Experiments): A Public-private Partnership Benchmarking Initiative to Enable the Development of Computational Methods for Hit-finding, S. Ackloo, R. Al-awar, R. E. Amaro, C. H. Arrowsmith, H. Azevedo, R. A. Batey, Y. Bengio, U. A. K. Betz, C. G. Bologa, J. D. Chodera, W. D. Cornell, I. Dunham, G. F. Ecker, K. Edfeldt, A. M. Edwards, M. K. Gilson, C. R. Gordijo, G. Hessler, A. Hillisch, A. Hogner, J. J. Irwin, J. M. Jansen, D. Kuhn, A. R. Leach, A. A. Lee, U. Lessel, J. Moult, I. Muegge, T. I. Oprea, B. G. Perry, P. Riley, K. S. Saikatendu, V. Santhakumar, M. Schapira, C. Scholten, M. H. Todd, M. Vedadi, A. Volkamer, T. M. Willson, Nat. Rev. Chem. 2022, DOI: 10.1038/s41570-022-00363-z (Preprint, DOI: 10.33774/chemrxiv-2021-rzq4n.)

  2. Target 2035 – Update on the Quest for a Probe for every Protein, S. Müller, S. Ackloo, A. Al Chawaf, B. Al-Lazikani, A. Antolin, J. B Baell, H. Beck, S. Beedie, U. A. K. Betz, G. A. Bezerra, P. E Brennan, D. Brown, P. J Brown, A. N Bullock, A. J Carter, A. Chaikuad, M. Chaineau, A. Ciulli, I. Collins, J. Dreher, D. Drewry, K. Edfeldt, A. M. Edwards, U. Egner, S. V. Frye, S. M. Fuchs, M. D. Hall, I. V. Hartung, A. Hillisch, S. H. Hitchcock, E. Homan, N. Kannan, J. R. Kiefer, S. Knapp, M. Kostic, S. Kubicek, A. R. Leach, S. Lindemann, B. D. Marsden, H. Matsui, J. L. Meier, D. Merk, M. Michel, M. R. Morgan, A. Mueller-Fahrnow, D. R. Owen, B. G. Perry, S. H. Rosenberg, K. S. Saikatendu, M. Schapira, C. Scholten, S. Sharma, A. Simeonov, M. Sundström, G. Superti-Furga, M. H. Todd, C. Tredup, M. Vedadi, F. von Delft, T. M. Willson, G. E. Winter, P. Workman and C. H Arrowsmith, RSC Med. Chem. 2021, 13, 13-21. DOI: 10.1039/D1MD00228G

  3. Screening the Pandemic Response Box Identified Benzimidazole Carbamates, Olorofim and Ravuconazole as Promising Drug Candidates for the Treatment of Eumycetoma, W. Lim, B. Nyuykonge, K. Eadie, M. Konings, J. Smeets, A. Fahal, A. Bonifaz, M. Todd, B. Perry, K. Samby, J. Burrows, A. Verbon and W. van de Sande PLoS NTD 2022, 16, e0010159. DOI: 10.1371/journal.pntd.0010159

2021

  1. Platinum Binding Preferences Dominate the Binding of Novel Polyamide Amidine Anthraquinone Platinum(II) Complexes to DNA, A. T. S. Lo, J. K. Chen, V. Murray, M. H. Todd and T. W. Hambley, Dalton Trans. 2021, 50, 17945-17952. DOI: 10.1039/D1DT03539H. Selected as a Dalton Transactions HOT article.

  2. An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials, E. G. Tse, L. Aithani, M. Anderson, J. Cardoso-Silva, G. Cincilla, G. J. Conduit, M. Galushka, D. Guan, I. Hallyburton, B. W. J. Irwin, K. Kirk, A. M. Lehane, J. C. R. Lindblom, R. Lui, S. Matthews, J. McCulloch, A. Motion, H. L. Ng, M. Öeren, M. N. Robertson, V. Spadavecchio, V. A. Tatsis, W. P. van Hoorn, A. D. Wade, T. M. Whitehead, P. Willis and M. H. Todd, J. Med. Chem. 2021, 64, 16450-16463. DOI: 10.1021/acs.jmedchem.1c00313 (Preprint)

  3. Novel Polyamide Amidine Anthraquinone Platinum(II) Complexes: Cytotoxicity, Cellular Accumulation, and Fluorescence Distributions in 2D and 3D Cell Culture Models, A, T. S. Lo, N. S. Bryce, A. V. Klein, M. H. Todd and T. W. Hambley, J. Biol. Inorg. Chem. 2021, 26, 217-233. DOI: 10.1007/s00775-020-01847-3

  4. Copper(II) Complexes of N-Propargyl Cyclam Ligands Reveal a Range of Coordination Modes and Colours, and Unexpected Reactivity, A. J. Counsell, M. Yu, M. Shi, A. T. Jones, J. M. Batten, P. Turner, M. H. Todd and P. J. Rutledge, Dalton Trans. 2021, 50, 3931-3942. DOI: 10.1039/D0DT03736B

  5. Molecular Docking with Open Access Software: Development of an Online Laboratory Handbook and Remote Workflow for Chemistry and Pharmacy Master’s Students to Undertake Computer-Aided Drug Design. B. Clent, Y. Wang, H. Britton, F. Otto, C. Swain, M. H. Todd, J. Wilden and A. Tabor, J. Chem. Ed. 2021, 98, 2899-2905. DOI: 10.1021/acs.jchemed.1c00289

  6. There is No Market for New Antibiotics: This Allows an Open Approach to Research and Development, D. M. Klug, F. I. M. Idiris, M. A. T. Blaskovich, F. von Delft, C. G. Dowson, C. Kirchhelle, A. P. Roberts, A. C. Singer and M. H. Todd, Wellcome Open Res. 2021, 6:146. DOI: 10.12688/wellcomeopenres.16847.1

  7. A Critical Overview of Computational Approaches Employed for COVID-19 Drug Discovery, E. N. Muratov, R. Amaro, C. H. Andrade, N. Brown, S. Ekins, D. Fourches, O. Isayev, D. Kozakov, J. Medina-Franco, K. M. Merz, T. I. Oprea, V. Poroikov, G. Schneider, M. H. Todd, A. Varnek, D. A. Winkler, A. Zakharov, A. Cherkasov and A. Tropsha, Chem. Soc. Rev. 2021, 50, 9121-9151. DOI: 10.1039/D0CS01065K

2020

  1. Open Science Approaches to COVID-19. E. G. Tse, D. M. Klug and M. H. Todd, F1000Research 2020 9:1043. DOI: 10.12688/f1000research.26084.1

  2. tele-Substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo(4,3-a)pyrazine-Based Antimalarials. M. Korsik, E. G. Tse, D. G. Smith, W. Lewis, P. J. Rutledge, and M. H. Todd, J. Org. Chem. 2020, 85, 13438-13452. DOI: 10.1021/acs.joc.0c01045

  3. Non-Classical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open Source Antimalarials. E. G. Tse, S. D. Houston, C. M. Williams, G. P. Savage, L. M. Rendina, I. Hallyburton, M. Anderson, R. Sharma, G. S. Walker, R. S. Obach and M. H. Todd, J. Med. Chem. 2020, 63, 11585-11601. DOI: 10.1021/acs.jmedchem.0c00746

  4. Metal Complexes as a Promising Source for New Antibiotics, A. Frei, J. Zuegg, A. G. Elliott, M. Baker, S. Braese, C. Brown, F. Chen, C. Dowson, G. Dujardin, N. Jung, A. P. King, A. M. Mansour, M. Massi, J. Moat, H. A. Mohamed, A. K. Renfrew, P. J. Rutledge, P. J. Sadler, M. H. Todd, C. E. Willans, J. J. Wilson, M. A. Cooper and M. A. T. Blaskovich, Chem. Sci. 2020, 11, 2627-2639. DOI: 10.1039/C9SC06460E

2019

  1. Six Laws of Open Source Drug Discovery, M. H. Todd, ChemMedChem 2019, 14, 1804–1809. DOI: 10.1002/cmdc.201900565 (Invited Guest Editorial)

  2. The Past, Present and Future of Anti-Malarial Medicines, E. G. Tse, M. Korsik and M. H. Todd, Malaria J. 2019, 18:93. DOI: 10.1186/s12936-019-2724-z (Living Review Version)

2018

  1. Easy-to-Synthesize Spirocyclic Compounds Possess Remarkable In Vivo Activity Against Mycobacterium Tuberculosis, A. Guardia, J. Baiget, M. Cacho, A. Pérez, M. Ortega-Guerra, W. Nxumalo, S. D. Khanye, J. Rullas, F. Ortega, E. Jiménez, E. Pérez-Herrán, M. T. Fraile-Gabaldón, J. Esquivias, R. Fernández, E. Porras-De Francisco, L. Encinas, M. Alonso, I. Giordano, C. Rivero, J. Miguel-Siles, J. G. Osende, K. A. Badiola, P. J. Rutledge, M. H. Todd, M. Remuiñán and C. Alemparte, J. Med. Chem. 2018, 61, 11327–11340. DOI: 10.1021/acs.jmedchem.8b01533

  2. Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities, S. Munawar, M. J Windley, E. G. Tse, M. H. Todd, A. Hill, J. Vandenberg and I. Jabeen, Frontiers Pharmacol. 2018, 9:1035. DOI: 10.3389/fphar.2018.01035

  3. Addressing the Most Neglected Diseases through an Open Research Model: the Discovery of Fenarimols as Novel Drug Candidates for Eumycetoma, W. Lim, Y. Melse, M. Konings, H. P. Duong, K. Eadie, B. Laleu, B. Perry, M. H. Todd, J.-R. Ioset, W. W. J. van de Sande, PLoS NTD 2018, 12(4): e0006437. DOI: 10.1371/journal.pntd.0006437 (Preprint)

  4. Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies, M. Spain, J. K.-H. Wong, G. Nagalingam, J. M. Batten, E. Hortle, S. Oehlers, X.-F. Jiang, H. E. Murage, J. T. Orford, P. Crisologo, J. A. Triccas, P. J. Rutledge and M. H. Todd, J. Med. Chem. 2018, 61, 3595–3608. DOI: 10.1021/acs.jmedchem.7b01569

  5. The C6H6 NMR Repository: an Integral Solution to Control the Flow of your Data from the Magnet to the Public, L. Patiny, M. Zasso, D. Kostro, A. Bernal, A. M. Castillo, A. Bolaños, M. A. Asencio, N. Pellet, M. H. Todd, N. Schloerer, S. Kuhn, E. Holmes, S. Javor and J. Wist, Mag. Res. Chem. 2018, 56, 520-528. DOI: 10.1002/mrc.4669

  6. Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands, Y. H. Lau, J. K. Clegg, J. R. Price, R. B. Marquart, M. H. Todd and P. J. Rutledge, Chem. Eur. J. 2018, 24, 1573-1585. DOI: 10.1002/chem.201703488

2017

  1. N-Aryl Groups are Ubiquitous in Cross Dehydrogenative Couplings Because They Stabilize Reactive Intermediates, A. S.-K. Tsang, A. S. K. Hashmi, P. Comba, M. Kerscher, B. Chan and M. H. Todd, Chem. Eur. J. 2017, 23, 9313–9318. DOI: 10.1002/chem.201700430

  2. An Open Source Pharma Roadmap, M. Balasegaram, P. Kolb, J. McKew, J. Menon, P. Olliaro, T. Sablinski, Z. Thomas, M. H. Todd, E. Torreele and J. Wilbanks, PLoS Med. 2017, 14(4): e1002276. DOI: 10.1371/journal.pmed.1002276 (Explainer piece in the Guardian)

  3. Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing, J. K.-H. Wong, M. H. Todd and P. J. Rutledge, Molecules 2017, 22, 200. DOI: 10.3390/molecules22020200 (Invited Contribution to Special Issue on Molecular Imaging Probes)

  4. Selective Displacement of a Scorpionand Triazole Ligand from Metallo-Cyclam Complexes Visualised Using NMR Spectroscopy, J. K.-H. Wong, N. Proschogo, M. H. Todd and P. J. Rutledge, Eur. J. Inorg. Chem. 2017, 7, 1075–1086. DOI: 10.1002/ejic.201601474 (Highlighted as a Very Important Paper)

2016

  1. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles, A. E. Williamson, P. M. Ylioja, M. N. Robertson, Y. Antonova-Koch, V. Avery, J. B. Baell, H. Batchu, S. Batra, J. N. Burrows, S. Bhattacharyya, F. Calderon, S. A. Charman, J. Clark, B. Crespo, M. Dean, S. L. Debbert, M. Delves, A. S. M. Dennis, F. Deroose, S. Duffy, S. Fletcher, G. Giaever, I. Hallyburton, F.-J. Gamo, M. Gebbia, R. K. Guy, Z. Hungerford, K. Kirk, M. J. Lafuente-Monasterio, A. Lee, S. Meister, C. Nislow, J. P. Overington, G. Papadatos, L. Patiny, J. Pham, S. A. Ralph, A. Ruecker, E. Ryan, C. Southan, K. Srivastava, C. Swain, M. J. Tarnowski, P. Thomson, P. Turner, I. M. Wallace, T. N. C. Wells, K. White, L. White, P. Willis, E. A. Winzeler, S. Wittlin, and M. H. Todd, ACS Cent. Sci. 2016, 2, 687–701. DOI: 10.1021/acscentsci.6b00086 (Paper Featured in the Sydney Morning Herald, El Mundo (Spanish language newspaper), IFL Science, Campus Review, ABC TV and Radio, Channel 10 television news, Radio Adelaide and an interview for the 2016 shareholder video for the pharmaceutical company GlaxoSmithKline (collaborators on the project); led to invited lay summary in The Conversation (Sept 14th 2016) and a Reddit Ask Me Anything online Q&A published in The Winnower)

  2. A Direct Method for the N-Tetraalkylation of Azamacrocycles, A. J. Counsell, A. T. Jones, M. H. Todd and P. J. Rutledge, Beilstein J. Org. Chem. 2016, 12, 2457-2461. DOI: 10.3762/bjoc.12.239

  3. SCINDR - The SCience INtroDuction Robot that will Connect Open Scientists, C. Smith, M. H. Todd, L. Patiny, C. Swain, C. Southan, A. E. Williamson and A. Clark, Res. Ideas Outcomes 2016, 2:e9995. DOI: 10.3897/rio.2.e9995

  4. Synthesis and Evaluation of 1,8-Disubstituted-cyclam/naphthalimide Conjugates as Probes for Metal Ions, J. K.-H. Wong, S. Ast, M. Yu, R. Flehr, A. J. Counsell, P. Turner, P. Crisologo, M. H. Todd and P. J. Rutledge, ChemistryOpen 2016, 5, 375–385. DOI: 10.1002/open.201600010

  5. Non-Toxic Metal-Cyclam Complexes, a New Class of Compounds with Potency Against Drug-Resistant Mycobacterium tuberculosis, M. Yu, G. Nagalingam, S. Ellis, E. Martinez, V. Sintchenko, M. Spain, P. J. Rutledge, M. H. Todd and J. Triccas, J. Med. Chem. 2016, 59, 5917–5921. DOI: 10.1021/acs.jmedchem.6b00432

2015

  1. Efficient Deprotection of F-BODIPY Derivatives: Removal of BF2 using Brønsted Acids, M. Yu, J. K.-H. Wong, C. Tang, P. Turner, M. H. Todd and P. J. Rutledge, Beilstein J. Org. Chem. 2015, 11, 37–41. DOI: 10.3762/bjoc.11.6

  2. Using Click Chemistry to Tune the Properties and the Fluorescence Response Mechanism of Structurally Similar Probes for Metal Ions, S. Ast, S. Kuke, P. J. Rutledge and M. H. Todd, Eur. J. Inorg. Chem. 2015, 58-66. DOI: 10.1002/ejic.201402811

  3. Experiences with LabTrove, a Researcher-Centric ELN, K. A. Badiola, C. Bird, W. S. Brocklesby, J. Casson, R. T. Chapman, S. J. Coles, J. R. Cronshaw, A. Fisher, J. G. Frey, D. Gloria, M. C. Grossel, D. B. Hibbert, L. K. Mapp, B. Matthews, A. Milsted, R. S. Minns, K. T. Mueller, K. Murphy, C. Neylon, T. Parkinson, R. Quinnell, J. S. Robinson, M. N. Robertson, M. Robins, E. Springate, G. Tizzard, M. H. Todd, A. E. Williamson, C. Willoughby, E. Yang and P. M. Ylioja, Chem. Sci. 2015, 6, 1614-1629. DOI: 10.1039/C4SC02128B

2014

  1. Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science, K. A. Badiola, D. H. Quan, J. A. Triccas and M. H. Todd, PLoS ONE 2014, 9(12): e111782. DOI: 10.1371/journal.pone.0111782

  2. pH-Responsive Quantum Dots (RQDs) that Combine a Fluorescent Nanoparticle with a pH-Sensitive Dye, S. Ast, P. J. Rutledge and M. H. Todd, Phys. Chem. Chem. Phys. 2014, 16, 25255-25257. DOI: 10.1039/C4CP03914A

  3. Neuroprotective Peptide-Macrocycle Conjugates Reveal Complex Structure-Activity Relationships in their Interactions with Amyloid ß, M. Yu, T. M. Ryan, S. Ellis, A. I. Bush, J. A. Triccas, P. J. Rutledge and M. H. Todd, Metallomics 2014, 6, 1931-1940. DOI: 10.1039/C4MT00122B

  4. The Properties and Performance of a pH-Responsive Functionalised Nanoparticle, S. Ast, P. J. Rutledge and M. H. Todd, Faraday Discuss. 2014, 175, 171-187. DOI: 10.1039/C4FD00110A (paper associated discussion: Faraday Discuss. 2014, 175, 215-227. DOI: 10.1039/C4FD90079K)

  5. Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni, I. Meister, K. Ingram-Sieber, N. Cowan, M. H. Todd, M. N. Robertson, C. Meli, M. Patra, G. Gasser and J. Keiser, Antimicrob. Ag. Chemother. 2014, 58, 5466-5472. DOI: 10.1128/AAC.02741-14

  6. Separation of Enantiomers: Synthetic Methods, M. H. Todd, Ed. Wiley-VCH, 2014. Includes:
    • Chapter 1: Introduction: A Survey of How and Why to Separate Enantiomers, M. H. Todd, 2014. (Open Access)
    • Chapter 7: Rare, Neglected and Potential Synthetic Methods for the Separation of Enantiomers, M. H. Todd, 2014. (Closed Access)
    • Review by Richard Kellogg published in Angewandte Chemie described it as “a thoughtfully constructed, and well-written book full of useful information”

  7. Mechanisms of Cross-Dehydrogenative-Coupling Reactions, A. S.-K. Tsang, S. J. Park and M. H. Todd, in From C–H to C–C Bonds: Cross Dehydrogenative Coupling, C.-J. Li, Ed., 2014, Royal Society of Chemistry, Cambridge.

  8. Incorporating a Piperidinyl Group in the Fluorophore Extends the Fluorescence Lifetime of Click-Derived Cyclam-Naphthalimide Conjugates, M. Yu, S. Ast, Q. Yu, A. T. S. Lo, R. Flehr, M. H. Todd and P. J. Rutledge, PLoS ONE 2014, 9(7):e100761. DOI: 10.1371/journal.pone.0100761

  9. Open Source Drug Discovery – A Limited Tutorial, M. N. Robertson, P. M. Ylioja, A. E. Williamson, M. Woelfle, M. Robins, K. A. Badiola, P. Willis, P. Olliaro, T. N. C. Wells and M. H. Todd, Parasitology 2014, 141, 148-157. DOI: 10.1017/S0031182013001121

2013

  1. In Vitro Metabolic Profile and In Vivo Antischistosomal Activity Studies of (η6-Praziquantel)Cr(CO)3 Derivatives, M. Patra, K. Ingram, A. Leonidova, V. Pierroz, S. Ferrari, M. N. Robertson, M. H. Todd, J. Keiser and G. Gasser, J. Med. Chem. 2013, 56, 9192-9198. DOI: 10.1021/jm401287m

  2. Synthesis of Elongated Cavitands via Click Reactions and their use as Chemosensors, Z. Csók, T. Kégl, Y. Li, R. Skoda-Földes, L. Kiss, S. Kunsági-Máté, M. H. Todd and L. Kollár, Tetrahedron 2013, 69, 8186-8190. DOI: 10.1016/j.tet.2013.07.044

  3. Ten Simple Rules for Cultivating Open Science and Collaborative R&D, H. Masum, A. Rao, B. M. Good, M. H. Todd, A. M. Edwards, L. Chan, B. A. Bunin, A. I. Su, Z. Thomas and P. E. Bourne, PLoS Comp. Biol. 2013, 9, e1003244. DOI: 10.1371/journal.pcbi.1003244

  4. Enhancing the Usefulness of Cross Dehydrogenative Coupling Reactions with a Removable Protecting Group, A. S.-K. Tsang, K. Ingram, J. Keiser, B. Hibbert and M. H. Todd, Org. Biomol. Chem. 2013, 11, 4921-4924. DOI: 10.1039/C3OB40503F

  5. Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity Without Inducing Cytotoxicity, M. Yu, N. H. Lim, S. Ellis, H. Nagase, J. A. Triccas, P. J. Rutledge and M. H. Todd, ChemistryOpen 2013, 2, 99-105. DOI: 10.1002/open.201300014

  6. A Fluorescent “Allosteric Scorpionate” Complex Visualizes a Biological Recognition Event, M. Yu, P. J. Rutledge and M. H. Todd, ChemBioChem 2013, 14, 224-229. DOI: 10.1002/cbic.201200637

  7. The Synaptic Leap: Open Science Combating Disease, P. Parker, B. Schwendimann, K. Thompson and M. H. Todd, in Architecture of Productive Learning Networks, L. Carvalho and P. Goodyear, Eds., 2013, Routledge (ISBN 978-0-415-81655-7)

2012

  1. Reversing the Triazole Topology in a Cyclam-Triazole-Dye Ligand Gives a 10-fold Brighter Signal Response to Zn2+ in Aqueous Solution, S. Ast, P. J. Rutledge and M. H. Todd, Eur. J. Inorg. Chem. 2012, 5611-5615. DOI: 10.1002/ejic.201201072

  2. The Outcome of the Oxidations of Unusual Enediamide Motifs is Governed by the Stabilities of the Intermediate Iminium Ions, M. Ahamed, B. Chan and M. H. Todd, PLoS ONE, 2012, 7(10):e47224. DOI: 10.1371/journal.pone.0047224

  3. The First Catalytic, Enantioselective Aza-Henry Reaction of an Unactivated Cyclic Imine, N. R. Amarasinghe, P. Turner and M. H. Todd, Adv. Synth. Catal. 2012, 354, 2954-2958. DOI: 10.1002/adsc.201200558

  4. Oxidative Arylation of Isochroman, S. J. Park, J. Price and M. H. Todd, J. Org. Chem. 2012, 77, 949-955. DOI: 10.1021/jo2021373

2011

  1. Copper, Nickel and Zinc Cyclam-Amino Acid and Cyclam-Peptide Complexes may be Synthesized with “Click” Chemistry and are Noncytotoxic, M. Yu, J. Price, P. Jensen, T. Shelper, C. Lovitt, S. Duffy, L. Windus, V. Avery, P. J. Rutledge and M. H. Todd, Inorg. Chem. 2011, 50, 12823-12835. DOI: 10.1021/ic2020012

  2. Open Science is a Research Accelerator, M. Woelfle, P. Olliaro and M. H. Todd, Nat. Chem. 2011, 3, 745-748. DOI: 10.1038/nchem.1149 (Mentioned on the cover; Discussed here and here)

  3. Resolution of Praziquantel, M. Woelfle, J.-P. Seerden, J. de Gooijer, K. Pouwer, P. Olliaro and M. H. Todd, PLoS Negl. Trop. Dis. 2011, 5(9):e1260. DOI: 10.1371/journal.pntd.0001260 (Picked up on the WHO website and evaluated on the F1000 website; A thorough meta-analysis of the project was published)

  4. Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal, A. T. S. Lo, N. K. Salam, D. E. Hibbs, P. J. Rutledge and M. H. Todd, PLoS One 2011, 6(5):e17446. DOI: 10.1371/journal.pone.0017446

  5. Chemical Sensors that Incorporate Click-Derived Triazoles, Y. H. Lau, P. J. Rutledge, M. Watkinson and M. H. Todd, Chem. Soc. Rev. 2011, 40, 2848-2866. DOI: 10.1039/C0CS00143K

  6. A Oxidative Carbon-Carbon Bond-Forming Reaction Proceeds via an Isolable Iminium Ion, A. S.-K. Tsang, P. Jensen, J. M. Hook, A. S. K. Hashmi and M. H. Todd, Pure Appl. Chem. 2011, 83, 655-665. DOI: 10.1351/PAC-CON-11-01-01

  7. A Treasure Hunt for Chemistry, A. J. Bridgeman, R. Connor, P. J. Rutledge and M. H. Todd, J. Chem. Ed. 2011, 88, 437-439. DOI: 10.1021/ed100867m (Featured in the journal editorial)

  8. A Click Fluorophore Sensor that can Distinguish CuII and HgII via Selective Anion-Induced Demetallation, Y. H. Lau, J. Price, M. H. Todd and P. J. Rutledge, Chem. Eur. J. 2011, 17, 2850-2858. DOI: 10.1002/chem.201002477 (Paper featured in Chemistry Views and selected as the journal frontispiece)

2010

  1. Gold Catalysis: Reactions of Organogold Compounds with Electrophiles, A. S. K. Hashmi, T. D. Ramamurthi, M. H. Todd, A. S.-K. Tsang and K. Graf, Aust, J. Chem. 2010, 63, 1619-1626. DOI: 10.1071/CH10342

  2. Aza-Henry Reactions of 3,4-Dihydroisoquinoline, M. Ahamed, T. Thirukkumaran, W. Y. Leung, P. Jensen, J. Schroers and M. H. Todd, Eur. J. Org. Chem. 2010, 5980-5988. DOI: 10.1002/ejoc.201000955

  3. Catalytic, Asymmetric Additions of Carbon-Centered Nucleophiles to Nitrogen-Containing Heterocycles, M. Ahamed and M. H. Todd, Eur. J. Org. Chem. 2010, 5935-5942. DOI: 10.1002/ejoc.201000877

  4. Cyclam-based “Clickates”: Homogeneous and Heterogeneous Fluorescent Sensors for Zn(II), E. Tamanini, K. Flavin, M. Motevalli, S. Piperno, L. A. Gheber, M. H. Todd and M. Watkinson, Inorg. Chem. 2010, 49, 3789-3800. DOI: 10.1021/ic901939x

2009

  1. Can We Measure Catalyst Efficiency in Asymmetric Chemical Reactions? A Theoretical Approach, S. El-Fayyoumy, M. H. Todd and C. J. Richards, Beilstein J. Org. Chem. 2009, 5, No. 67. DOI: 10.3762/bjoc.5.67 (The Jones group at the University of Sheffield have set up an ACES calculator)

  2. Kernel for Tropical Disease Initiative, L. Ortí, R. J. Carbajo, U. Pieper, N. Eswar, S. M. Maurer, A. K. Rai, G. Taylor, M. H. Todd, A. Pineda-Lucena, A. Sali and M. A. Marti-Renom, Nature Biotech. 2009, 27, 320-321. DOI: 10.1038/nbt0409-320

  3. Chemotherapeutic Development Strategies for Schistosomiasis, C. R. Caffrey, D. L. Williams, M. H. Todd, D. L. Nelson, J. Keiser and J. Utzinger, in Drug Discovery in Infectious Diseases: from Molecular Targets to Drug Candidates, P. M. Selzer, Ed., 2009, Wiley-VCH, Weinheim.

  4. Responsive Metal Complexes: A Click-Based “Allosteric Scorpionate” Complex Permits the Detection of a Biological Recognition Events by EPR/ENDOR Spectroscopy, E. Tamanini, S. E. J. Rigby, M. Motevalli, M. H. Todd and M. Watkinson, Chem. Eur. J. 2009, 15, 3720-3728. DOI: 10.1002/chem.200802425

  5. A Synthetically Simple, Click-generated Cyclam-based Zinc(II) Sensor, E. Tamanini, A. Katewa, L. M. Sedger, M. H. Todd and M. Watkinson, Inorg. Chem. 2009, 48, 319-324. DOI: 10.1021/ic8017634

  6. A Kernel for Open Source Drug Discovery in Tropical Diseases, L. Ortí, R. J. Carbajo, U. Pieper, N. Eswar, S. M. Maurer, A. K. Rai, G. Taylor, M. H. Todd, A. Pineda-Lucena, A. Sali and M. A. Marti-Renom, PLoS Negl. Trop. Dis. 2009, 3(4):e418. DOI: 10.1371/journal.pntd.0000418

  7. Facile Synthesis of Vicinal Diamines via Oxidation of N-phenyltetrahydroisoquinolines with DDQ, A.-S. K. Tsang and M. H. Todd, Tetrahedron Lett. 2009, 50, 1199-1202. DOI: 10.1016/j.tetlet.2008.12.101

2008

  1. Synthesis and DNA Binding Ability of Cyclam-Amino Acid Conjugates, A. V. Ramana, M. Watkinson and M. H. Todd, Bioorg. Med. Chem. Lett. 2008, 18, 3007-3010. DOI: 10.1016/j.bmcl.2008.03.045

2007

  1. Effective Methods for the Biotinylation of Azamacrocycles, S. Krivickas, E. Tamanini, M. H. Todd and M. Watkinson, J. Org. Chem. 2007, 72, 8280-8289. DOI: 10.1021/jo071175v

  2. Is Actin the Praziquantel Receptor?, A. R. Troiani, L. Pica-Mattoccia, C. Valle, D. Cioli, G. Mignogna, F. Ronketti and M. H. Todd, Int. J. Antimicrob. Ag. 2007, 30, 280-281. DOI: 10.1016/j.ijantimicag.2007.05.004

  3. Praziquantel Derivatives I: Modification of the Aromatic Ring, F. E. Ronketti, A. V. Ramana, X. Chao-Ming, L. Pica-Mattoccia, D. Cioli and M. H. Todd, Bioorg. Med. Chem. Lett. 2007, 17, 4154-4157. DOI: 10.1016/j.bmcl.2007.05.063

  4. Open Access and Open Source in Chemistry, M. H. Todd, Chem. Central J. 2007, 1:3. DOI: 10.1186/1752-153X-1-3

2006

  1. The Effects of Drugs, Ions and Poly-L-lysine on the Excretory System of Schistosoma mansoni, J. R. Kusel, F. Oliveira, M. H. Todd, F. Ronketti, S. Lima, A. C.- de Mattos, K. Teixeira, P. M. Z. Coelho, J. A. Thornhill and F. Ribeiro, Mem. Inst. Oswaldo Cruz. 2006, 101(Suppl 1), 293-298. DOI: 10.1590/S0074-02762006000900046

  2. Improved Synthesis of the Valuable Peptidomimetic Intermediate 3-Azido-4-hydroxy Cyclopentanoic Acid, E. Tamanini, M. Watkinson and M. H. Todd, Tetrahedron Asymmetry 2006, 17, 2235-2239. DOI: 10.1016/j.tetasy.2006.07.001

  3. Open Source Research – the Power of Us, T. B. Kepler, M. A. Marti-Renom, S. M. Maurer, A. K. Rai, G. Taylor and M. H. Todd, Aust. J. Chem. 2006, 59, 291-294. DOI: 10.1071/CH06095

  4. Solid Phase Synthesis of Praziquantel, S. El-Fayoummy, W. Mansour and M. H. Todd, Tetrahedron Lett. 2006, 47, 1287-1290. DOI: 10.1016/j.tetlet.2005.12.073

  5. (R)-2-Ferrocenyl-4-hy­droxy­methyl-4,5-di­hydro-1,3-oxazole, M. H. Todd, S. El-Fayyoumy, M. E. Motevalli and C. J. Richards, Acta Cryst. E. 2006, E62, m719-m720. DOI: 10.1107/S1600536806006982

  6. Design and Synthesis of New Tetrazolyl- and Carboxy-biphenylylmethyl-quinazolin-4-one Derivatives as Angiotensin II AT1 Receptor Antagonists, M. A. H. Ismail, S. Barker, D. A. Abou El Ella, K. A. M. Abouzid and R. A. Toubar and M. H. Todd, J. Med. Chem. 2006, 49, 1526-1535. DOI: 10.1021/jm050232e

2005

  1. Computer-Aided Organic Synthesis, M. H. Todd, Chem. Soc. Rev. 2005, 34, 247-266. DOI: 10.1039/B104620A

2003

  1. Drugs for the Control of Parasitic Diseases: Current Status and Development in Schistosomiasis, A. Fenwick, L. Savioli, D. Engels, R. Bergquist and M. H. Todd, Trends Parasitol. 2003, 19, 509-515. DOI: 10.1016/j.pt.2003.09.005

2002

  1. Asymmetric Autocatalysis: Product Recruitment for the Increase in the Chiral Environment (PRICE), M. H. Todd, Chem. Soc. Rev. 2002, 31, 211-222. DOI: 10.1039/B104169J

  2. Use of FTICR-MS to Detect Chemical Tags from a Combinatorial Library, M. H. Todd and C. Abell, Analyst 2002, 127, 1399-1406. DOI: 10.1039/B203957P

  3. Amino Acid-Derived Heterocycles: Lewis Acid Catalyzed and Radical Cyclizations from Peptide Acetals, M. H. Todd, C. O. Ndubaku and P. A. Bartlett, J. Org. Chem. 2002, 67, 3985-3988. DOI: 10.1021/jo010990m

2001

  1. Novel Chemical Tagging Method for Combinatorial Synthesis Utilizing Suzuki Chemistry and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, M. H. Todd and C. Abell, J. Comb. Chem. 2001, 3, 319-327. DOI: 10.1021/cc000112m

2000

  1. The Attachment and Cleavage of Phenols from Solid Supports and their Single Bead Mass Spectral Analysis, M. H. Todd and C. Abell, Tetrahedron Lett. 2000, 41, 8183-8187. DOI: 10.1016/S0040-4039(00)01431-3

  2. Palladium-Catalyzed Carbon-Carbon Bond Formation on Solid Support, M. H. Todd and C. Abell, in Solid Phase Synthesis, Burgess, K. (Ed.), Wiley-Interscience (New York), 2000, 25-79.

1999

  1. A Novel Safety-Catch Linker for the Solid-Phase Synthesis of Amides and Esters, M. H. Todd, S. F. Oliver and C. Abell, Org. Lett. 1999, 1, 1149-1151. DOI: 10.1021/ol990785h

1997

  1. Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids, M. H. Todd, S. Balasubramanian and C. Abell, Tetrahedron Lett. 1997, 38, 6781-6784. DOI: 10.1016/S0040-4039(97)01552-9